IVCC Core Objectives for 2010-2015
- Advance and expand the portfolio of New Active Ingredient (AI) Discovery and Development programmes so as to provide three new Active Ingredients by 2020.
- Complete the development of the existing formulation and re-purposing portfolio to deliver products that will enable rational and effective resistance management programmes and reduce by ~25% the cost of application of IRS programmes.
- Establish a process and capability for the rapid assessment of the effectiveness of New Paradigms in Vector Control so as to increase the number of available interventions and define target product profiles for AI and formulations required so as to enable rapid development, widespread adoption of and effective use of those that are verified.
- Complete the development of a set of malaria and dengue control decision support systems, analytical tools and strategies, and establish an effective process for these products to be widely and sustainably implemented so as to enable effective disease control and resistance management programmes.
- Contribute to, and influence the global debate on innovative vector control and engage the processes of regulation, policy and advocacy to ensure swift and widespread adoption of best practice.
- Develop an organisation that is capable of delivering the ongoing Mission Statement of the IVCC, with an evidence based roadmap of future needs and a strategy for their resolution.
New Active Ingredients (AIs)
IVCC’s long term objectives call for the creation of three new active ingredients that are unaffected by current resistance mechanisms by 2020. Two substantial data mining rescreening programmes are under way to build the candidate base from which these AIs will be developed. In addition molecular design projects will provide targeted candidates for development. A third screening programme is at proof of concept stage and several other proposals are in preparation. It is well known that new AI discovery has a very high attrition rate and that success in this field requires the creation of a large and diverse pool of candidates.
Formulations and Re-purposing
The formulation and re-purposing development projects initiated in 2007 are planned to deliver, in 2012-2013, long lasting IRS products and insecticide combinations which will mitigate the effects of pyrethroid resistance. Our portfolio of Proof of Concept studies will give rise to a smaller number of re-purposing projects to be initiated in 2011, and yielding products in 2016 that will bring alternative agricultural insecticides to bear on the vector control market.
New Consumer Paradigm and Target Product Profile (TPP) for Vector Control
We have identified that a key barrier to innovation in vector control is the lack of an established consumer driven intervention paradigm. We have started the process of consultation with a broad range of stakeholders to develop a coherent, efficient process for the establishment of such a paradigm and plan to begin work to develop the products, protocols and distribution routes for such a product. Concepts for innovative product approaches to address this paradigm have already been proposed by our industry partners.
Verification of a new paradigm will feed back into the design of the new AI TPP and spark a new round of formulations designed to achieve that paradigm.
Information Systems and Tools
The IVCC projects in Information Systems and Tools will come to fruition in late 2010, and emerge as a series of first generation products. IVCC is currently planning the establishment of suitable vehicles to take these products forward and help the disease control programmes to implement them broadly and sustainably within the disease endemic countries.