Indoor Residual Sprays
There are currently 4 projects in the IRS formulation and re-purposing portfolio, two advanced projects with Bayer and Syngenta and a further 3 in the Proof of Concept stage projects with Bayer, BASF and Dupont.
The advanced projects with Bayer and Syngenta are targeted at increased IRS residuality with known, WHOPES approved, AIs. Lab trials have shown substantial improvements over the residuality of current formulations in both cases. Hut trials are under way and if these continue to be successful the Bayer deltamethrin and a non pyrethroid Syngenta LLIRS should achieve WHOPES recommendation in 2011 and a Bayer bendiocarb formulation in 2012. The consequence of this would be to give a long lasting formulation for every class of WHOPES approved insecticide maximising the opportunity for good product stewardship with known AIs. In addition these outcomes will set a new industry standard performance benchmark to which new products, including new AIs, will need to aspire.
The BASF and DuPont re-purposing proof of concept studies bring to public health applications three agricultural insecticide classes that have not been formulated and validated for use invector control. The key challenge here is to determine whether these insecticides, with very different modes of action from the current products, have value for use in IRS, and if so full development projects will follow.
Long Lasting Insecticide Treated Nets
The LLIN portfolio is still far from complete due to the lack of insecticides that combine the safety profile, the performance requirements and the formulation stability and surfaceaccessibility of the pyrethroids. This is an important part of the portfolio due to the widespread use of nets in vector control programmes and the emergence of resistance to pyrethroids in West Africa. Three proof of concept studies are aimed at this target.
All the proof of concept studies involve existing crop protection insecticides, either alone, or in bi-treatments with pyrethroids.
These proof of principle studies involve three different chemical classes from three companies including DuPont and BASF all of which would be new to vector control. By the end of 2009 the IVCC will know whether any of these projects is viable. These projects, if successful would result in products in the vector control market within 5 years of the commencement of a full project.
Current Formulation and Re-purposing Portfolio Position
Proposals for further projects are being developed with two other companies which could potentially bring new products for non pyrethroid LLINs and formulation technology for long lasting LLINs and IRS.
2010-2015: Plans for the Formulation and Re-purposing Project Portfolio
Long Lasting IRS projects
- Complete the current development projects with Syngenta and Bayer for long lasting formulations for currently approved insecticide classes.
- If any of the re-purposing proof of concept projects aresuccessful, develop full formulation projects to bring those through WHOPES and to market.
- Identify two new Proof of Concept studies for agricultural product re-purposing.
- Identify proof of concept studies for radically innovative IRS developments such as 6 year residual formulation concepts.
Long Lasting ITNs
- Execute full development projects on successful proof of concepts emerging from the current projects.
- Test speculative concepts for re-purposing or combination products with other identified partners.
- Identify further Proof of Concept opportunities.