Active Ingredient Portfolio
The search for new active ingredients suitable for public health insecticides is delivering promising results.
The cornerstone to IVCC’s mission is the development of three new active ingredients, each with a novel mode of action, in effect, a different way of killing mosquitoes. These will form the basis of a new generation of insecticides suitable for public health purposes.
The main objective of developing new active ingredients is to target the malaria transmitting mosquitoes, but they will also have wider application in controlling insects that transmit other diseases. Insecticide treated bednets and indoor residual spraying have proven to be effective methods of malaria vector control. But they depend on only four classes of insecticide for IRS and just one, the pyrethroids, for bednets. Insecticide resistance threatens the effectiveness of all four classes and resistance to pyrethroids has been detected in over 64 countries.
There has been no new public health insecticide for around 30 years and new insecticides are desperately needed. Without them insecticide resistance cannot be challenged. Working together with its partners in industry and academia and bringing together expertise and resources from across the board, IVCC is on target to deliver the new insecticides that are crucial to challenging insecticide resistance. IVCC’s active ingredient (AI) portfolio is on track and showing very promising results.
From libraries comprising of around 4 million chemical compounds, hundreds of thousands of chemical classes have been screened using IVCC Target Product Profiles to ensure suitability for purpose.Nine novel chemical classes have shown significant activity against adult mosquitoes and are ready to be moved into the candidate selection in the coming year. The next task is to choose three of these new active ingredients to take to full development, which will take about seven years.
Resistance develops more quickly when only one insecticide is used. By developing three new insecticides with different modes of action and using them in rotation or mixtures, malaria control programmes will have greater opportunities to ensure that the mosquito population has little chance of developing resistance.
The high level of commitment and support that IVCC has received from its industry partners has been invaluable. Without their hard work, the AI portfolio would not be where it is today, poised to enter the final development stages.