The aim of this project is to develop a long lasting residual formulation for Indoor Residual Spraying (IRS) programmes to improve malaria vector control in disease endemic countries. The formulation will use proprietary technology to dissolve an active ingredient into a polymer. The concept is based on the idea that a polymer can be used as a barrier between an AI and an aggressive surface, to increase the probability of producing a long lasting residual formulation.
The new formulation will reduce the cost and logistical problems associated with IRS spraying in endemic countries. Long lasting formulations would allow a reduction in the number of application rounds per year, significantly decreasing the application cost. The reduction in cost achieved would reduce IRS treatments to similar operational costs as current insecticide treated material types of control. Deltamethrin was used as the AI to develop the first new formulation.
Bayer have developed a deltamethrin formulation based on patented technology to deliver a long lasting residual effect. In laboratory trials it has shown 12 months residual effect on concrete and wood surfaces and nine months on mud surfaces. The experimental hut trial work is continuing, the latest data confirms residual activity up to 32 weeks on all surfaces. Bayer have taken the decision to commercialise the formulation and will take it through the WHOPES process and develop a regulatory package for the formulation.