The Bayer potential new insecticide
This project is focussed on the discovery of at least one novel contact insecticide, with a novel mode of action, and the potential to control malaria vectors. The new developed insecticide will not be affected by known resistance mechanisms in order to help mosquito control programmes manage resistance issues. The project is making use of Bayer’s historic chemical library to generate potential leads in order to develop totally new active ingredients for vector control insecticide products.
The project involves researching the chemical library for potential vector control insecticides using any data that has already been collected to identify compounds that may have activity. Once the compounds are selected they will be screened for activity against mosquitoes and their mode of action determined. The most interesting compounds from the initial screening programmes will be used to direct analogue synthesis to optimise the activity of a class of chemistry against adult mosquitoes whilst minimising the potential toxicity.
This project is due to run for three years and began in September 2009. Several interesting classes of chemistry have already been identified. This project is the first phase in the development of a new active ingredient for vector control that will take approximately 10 years to deliver a product to the market.