This project is aimed at identifying one or more lead areas of novel chemistry that are free of cross-resistance to existing chemistries used for adult mosquito control and are suitable for optimisation and potential development into products for the control of adult mosquitoes via appropriate delivery systems.
The project involves reviewing the available data from Syngenta’s historic chemical library and existing insecticide development projects to select compounds and classes of chemistry that have potential as vector control insecticides without any potential toxicological issues. These compounds are then screened against adult mosquitoes to produce portfolio of compound and chemical class hits to be reviewed as potential areas of chemistry to optimise in a later project.
Syngenta have completed their search of their historic chemical library and identified compounds for testing. They have developed an adult mosquito screening method. They have begun to screen these compounds and have already had a promising hit rate.
This project is due to run for one year and began in August 2009. This project is the first phase in the development of a new active ingredient for vector control that will take approximately 10 years to deliver a product to the market.