This report, Keeping The Promise: Product Development Partnerships’ Role in the New Age of Health Research and Product Development is a coordinated effort from 12 product development partnerships (PDPs) to highlight the unique capabilities and successes of these organisations in preventing and responding to both long-standing and emerging global health threats, including TB, HIV, malaria, a host of neglected diseases, COVID-19, antimicrobial resistance (AMR), and pandemic preparedness.