The Innovative Vector Control Consortium (IVCC) has helped the CREC/LSHTM Collaborative Research Programme in Benin achieve Good Laboratory Practice (GLP) certification, the second vector control field trial site to attain certification in Sub-Saharan Africa.
The CREC/LSHTM Collaborative Research Programme is a research partnership set up in 2003 between the London School of Hygiene & Tropical Medicine and the Centre de Recherche Entomologique de Cotonou (CREC) at the Ministry of Health in Benin.
The partnership has extensive experience in the evaluation of vector control products (mainly long-lasting insecticidal nets and Indoor residual spraying) to WHO standards. It is part of PAMVERC (The Pan-African Malaria Vector Research Consortium) and its research activities are largely funded by USAID and by the Bill & Melinda Gates Foundation (BMGF) through IVCC and collaborating agrochemical companies.
Nick Hamon, CEO of IVCC said: “Field trials facilities in Africa play an essential role in evaluating novel vector control products being developed by our agrochemical partners. The generation of reliable data through GLP compliant field trials is important, as this is the key to establishing the true performance of the products being tested.”
Since 2000, IVCC, in partnership with the London School of Hygiene & Tropical Medicine, has been working to strengthen the quality and reliability of data generated by African vector control field trial sites. This work has included the development of quality management systems including Standard Operating Procedures (SOPs), the auditing of facilities for GLP compliance, and GLP training workshops.
An important element of IVCC’s GLP rollout programme has also been its funding of infrastructure improvements including buildings and equipment at its collaborating trial sites. This research capacity building is establishing a network of facilities in Africa that can generate testing data on vector control products of the highest standard.
Dr. Corine Ngufor, Assistant Professor, Disease Control Department, London School of Hygiene and Tropical Medicine and Facility Manager of CREC/LSHTM Facility said: “GLP accreditation is never an easy process for any facility. CREC/LSHTM is now the first facility in the West African region and the second in Africa to achieve GLP accreditation for vector control product evaluation. We look forward to working with agrochemical companies to deliver high quality data on the efficacy of novel vector control products in line with the WHO pre-qualification requirements. As a team, we have worked hard over the past 2 years and are very proud of this achievement. We are also grateful for the support provided by IVCC through this process.”
Graham Small, IVCC’s Trials Quality and Project Support Manager added: “The growing network of GLP certified trials sites across Africa will allow manufacturers of vector control products to generate their own efficacy data for inclusion in their product dossiers submitted to the WHO Prequalification Team product evaluation process. This represents a major step forward for vector control product testing, which will be of major importance in delivering the IVCC mission and in achieving malaria elimination in the future.”
In 2016, the first field trial site to achieve GLP certification was the Kilimanjaro Christian Medical University College (KCMUCo) was in Moshi, Tanzania. Five further IVCC collaborating trials sites are now planning their GLP studies and will be submitting their applications for OECD GLP certification through SANAS in the coming year.IVCC Secures $18.75M Grant from Australian Government to Help Eradicate Malaria 9th May 2018
The Innovative Vector Control Consortium (IVCC) has been awarded a four-year A$18.75m grant by the Australian Government to help eradicate malaria and other deadly mosquito-borne diseases from the Indo-Pacific region.
As part of the Australian Government’s landmark Health Security Initiative which aims to improve the health security of developing countries who bear 99% of the world’s malaria burden, the Indo-Pacific Centre for Health Security will support IVCC in its development and dissemination of innovative vector control solutions to address the very real health threat of mosquito borne diseases in the Indo-Pacific region.
Nick Hamon, CEO of IVCC said: “IVCC has supported the development of vector control products since its inception in 2005. This has led to the release of game-changing tools to mitigate insecticide resistance build up. Together with the Australian Government and partners we look forward to leveraging and adapting this robust pipeline of innovative vector control solutions to maximise the opportunity to save lives in the Indo-Pacific region and help prevent the spread of vector borne diseases.”
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Let’s start at the end. If we could just keep mosquitoes from transmitting the parasites, we could stop the scourge of malaria. Mathematical modeling by Imperial College indicates that by the year 2040 we could save over 27 million lives in Africa, reduce malaria in children by 93%, prevent the loss of 3.8 billion farmer work days, and increase agricultural productivity by $295 billion. We should all be asking how we could possibly achieve this monumental improvement on the continent that most needs it. The answer could lie in the development and distribution of just three items: a sugar bait that kills mosquitoes, bed nets with combinations of insecticides that overcome resistance, and indoor wall sprays that only need to be applied once per year.
ZERO by 40 is an agreement among leading agricultural chemical companies currently involved in vector control in Africa to apply their skills and resources to the development of those three tools. None of them are pie-in-the-sky wish fulfillment – they can be ready in the next five years:
The sugar bait, called an Attractive Targeted Sugar Bait (ATSB), met and exceeded its expectations in African trials after nearly ten years of patient work by Westham Company. This tool kills mosquitoes in a completely new way, complementing traditional methods to achieve a very high level of control. The work ahead is detailed and sometimes frustrating, but at the end of the day, it is a matter of dotting I’s and crossing T’s.
The first combination nets (long-lasting insecticide-treated bed nets, or LLINs) are being distributed this year. Though these nets use the insecticide for which many mosquitoes have resistance, they overcome the resistance by adding one of several additional chemicals. Patient effort during 11 years by the Innovative Vector Control Consortium (IVCC) and its industrial partners is also producing completely new candidate insecticides that will only be used in Africa for public health, keeping those new compounds from suffering the fate of insecticide resistance.
Indoor wall sprays (indoor residual spray or IRS and an extra-long-lasting spray or XLLIRS) will also use some of the new chemicals. Through a combination of formulation and chemistry, production of products that last at least 12 months will revolutionize IRS. Smaller, professional spray crews will be able to work their way through a community on a continuous basis, escaping the inefficiency of seasonal programs timed to treat homes before the transmission season.
During the last year, the Gates Foundation, IVCC, Mitsui Chemical Company, Sumitomo Chemical Company, ChemChina/Syngenta, BASF, and Bayer Corporation have worked together from the very top of their organizations to the technical people who make things happen. This collaboration is based on commitment to public-health mosquito control and a willingness to cooperate with each other. Supported by two meetings with Bill Gates, this community is developing a feasible plan to reach an audacious goal – elimination of malaria from Africa by 2040.