In partnership with IVCC, and funded by the Bill & Melinda Gates Foundation, the Liverpool School of Tropical Medicine’s Centre for Capacity Research investigated how Good Laboratory Practice (GLP) certification was achieved by the KCMUCo-PAMVERC trial site in Moshi, Tanzania.
A new paper by Sara Begg identified the enablers and barriers that influenced the development of capacity to achieve GLP certification with the lessons learnt transferable to other African trial sites to accelerate progress towards GLP and strengthen the network of test facilities able to provide high-quality data for the evaluation of vector control products.Volcanic Glass Spray Shows Promise in Controlling Mosquitoes 9th June 2020
IVCC supports a study by North Carolina State University entomologists and Imerys Filtration Minerals Inc. to test an indoor residual spray made by combining a type of volcanic glass with water. In the study Imergard WP – an insecticide created from perlite – was tested. Researchers used the spray in experimental huts in the Republic of Benin to test the effects of the spray on both wild and more susceptible strains of Anopheles gambiae mosquitoes, the primary malaria vector in sub-Saharan Africa. Results showed mortality rates of mosquitoes alighting on Imergard WP treated walls were greater than 80% up to five months after treatments, and 78% at six months. The treatments were effective against both susceptible and wild-type mosquitoes.
Read the full press release on the NCSU website.
Photo credit: Dr. Bidossessi Deguenon, NCSUNgenIRS Evidence Launch 30th April 2020
“I am very pleased that together we achieved our goal of establishing a sustainable, growing and competitive market for third generation, longer lasting and resistance-breaking insecticides for Indoor Residual Spraying (IRS).”
On December 31st, 2019, the Unitaid funded NgenIRS project came to an end. The NgenIRS team, led by IVCC and made up of colleagues from PATH and Abt Associates, worked in partnership with 16 malaria control and elimination programmes across Africa, the US President’s Malaria Initiative (PMI), the Global Fund and three insecticide manufacturers.
The downward trend in IRS use was reversed and the resulting expansion of use has resulted in significant public health impact, savings in commodity costs and new evidence showing the cost-effectiveness of third generation IRS (3GIRS). What’s more, the foundation has been laid to sustain and expand on these successes, providing malaria programmes with more options for rotation and ultimately more lives saved on the path towards malaria elimination.
Today we launch a collection of evidence materials, consisting of a video, a project overview and evidence slides (available in both English and French). These materials are available for free download on the NgenIRS web page and IVCC resource library. These materials have been prepared to show the impact of the NgenIRS project and are intended for use by partners and stakeholders who need to communicate the contribution of 3GIRS products to the reduction of malaria. We hope that these are useful to you and advice on use can be found within the materials.
I would like to extend my heartfelt thanks to the NgenIRS team and our many other partners who worked tirelessly and selflessly to make this project such a huge success. Although we have achieved great things together, we must maintain this commitment to enhancing and smartly deploying the vector control toolbox if we are to reach our shared goal of malaria eradication.
View all evidence materials >COVID-19, Malaria and IVCC 6th April 2020
As the world grapples with the COVID-19 pandemic, there is a renewed awareness of the devastating effects of infectious diseases and the need for robust health and surveillance systems. COVID-19 is testing the resilience of these systems around the world and is now moving into resource-limited settings, where its impact could be even more devastating. Malaria-endemic countries across the globe have reported cases of COVID-19 and 37 countries in Africa (which carries more than 90% of the global malaria burden) had reported cases by 5th April 2020. Efforts to limit the spread of COVID-19 are necessary to allow health care systems to continue to serve their communities during this crisis.
At the same time, these efforts must not compromise access to life-saving malaria prevention, diagnosis and treatment services or threaten to reverse decades of hard-fought progress against malaria. Experience from previous disease outbreaks has shown the disruptive effect on health service delivery and the consequences for already vulnerable populations. COVID-19 is not the first reminder of the potentially delicate balance of global health challenges (Swine influenza in 2009, Ebola in 2014 and Zika virus in 2015) and it won’t be the last, although somehow it seems we forget and move on so quickly. Recognising this balance, the World Health Organization (WHO) has underlined the critical importance of continuing malaria prevention at this time. Ensuring access to vector control tools and products is an important strategy for reducing the strain on health systems. These vital tools include insecticide-treated nets (ITNs) and Indoor Residual Spraying (IRS) – which have been responsible for more than three quarters of averted clinical cases of malaria in the past 18 years.
In recent days, there have been reports of the suspension of vector control programmes in several African countries due to COVID-19. The WHO strongly encourages countries not to suspend the planning for or implementation of vector control activities, whilst, of course, taking all necessary precautions against spreading infection. There are also disruptions in the supply chains of essential vector control interventions, resulting from lockdowns and from a suspension of the importation and exportation of goods in response to COVID-19. Coordinated action is required to ensure the availability of these tools for the people who need them most and we are committed to contributing our expertise and networks to this end.
At IVCC, our vision is a world free of insect-borne disease, where lives are saved, and prosperity increased. Our strategy to reach this goal is to deliver a comprehensive toolbox of resistance-breaking vector control tools and to maximise their impact through market access interventions. During this time, we will continue to work in partnership with colleagues across the global health community to see this happen. The COVID-19 pandemic has demonstrated once again that we do not have all the tools needed to tackle infectious diseases and so, if anything, more innovation than ever is essential. Current investments in malaria are saving hundreds of thousands of lives and preventing millions of cases per year. This is significant progress but too many people continue to suffer and die. In 2018, there were an estimated 228 million cases of malaria worldwide and an estimated 405,000 deaths – of which two thirds were children under five in Africa. As long as malaria exists, it threatens the poorest and most vulnerable and has the potential to resurge in times of public health crises – like the one we are facing now.
Against the backdrop of COVID-19 it could be easy for malaria to be forgotten by the international community and for vital resource allocation to suffer, so we are incredibly grateful for the continued support, guidance and work of all our funders and partners. In recognition of the importance of not taking our foot off the pedal with malaria eradication, our funders have encouraged us to continue to support partners through the challenges of COVID-19. It is difficult to apply blanket rules but we are taking a flexible and pragmatic approach to adjusting workplans and contracts to ensure the continuation of delivery of programs; supporting reasonable costs to ensure that essential resources and expertise remain in place; and considering, in good faith, requests to re-profile and revise project budgets, timelines and milestones. It is due to this commitment by us all to stay the course, even in these unprecedented times, that we will reach a malaria-free world.
Our thoughts remain, always, with people in malaria-endemic countries, our partners globally and our colleagues – we hope that you stay safe and well, and remain committed to playing our part in that.
2 Billion Mosquito Nets Delivered Worldwide 16th January 2020
The RBM Partnership to End Malaria is leading the global malaria community in celebrating the milestone of 2 billion insecticide-treated mosquito nets (ITNs) delivered worldwide since 2004. The development and scale up of these nets are responsible for 68% of the malaria cases prevented in Africa since 2000, contributing to global efforts that saved more than 7 million lives and prevented more than 1 billion malaria cases.
A new video highlights the global collaboration it took to boost funding, pioneer, produce, and deliver the insecticide-treated mosquito nets to millions of families around the world living at risk of malaria, a preventable disease that kills a child every 2 minutes. The film follows the journey of one of the nets passed among representatives from the global malaria community including advocates, a scientist, global leaders and malaria-endemic country health workers to reach a family in Nampula, Mozambique – one of 5 countries with the highest burden of malaria. It also features a classroom of young women in Nyanza Province, Kenya, including Clementina Akinyi. Ms Akinyi, now in her last year of high school, grew up sleeping under insecticide-treated nets, and was photographed as a young child under a mosquito net – an image which became iconic for the fight against malaria.
According to the latest World Malaria Report, between 2010 and 2018, the number of pregnant women and children under 5 in sub-Saharan Africa who slept under an insecticide-treated net more than doubled, up from 26% to 61%. Key initiatives driving this progress include The Global Fund to Fight AIDS, Tuberculosis and Malaria and the U.S. President’s Malaria Initiative (PMI), which purchased and worked with malaria-endemic countries and partners to distribute 1.13 billion and 400 million insecticide-treated mosquito nets, respectively. Many other governments, notably the UK, and organisations, including UNICEF, International Federation of the Red Cross and Red Crescent Societies (IFRC), the World Bank, the United Nations Foundation’s Nothing But Nets initiative and Against Malaria Foundation, also made significant contributions to the 2 billion net milestone.
While current evidence suggests that nets treated with pyrethroid insecticides continue to be effective against the mosquito, resistance to pyrethroids – the only insecticide class currently used in ITNs – is widespread and highest in the WHO African Region. To combat insecticide resistance, partners are developing, testing and scaling up nets with new insecticide combinations and harnessing data to better target where to distribute current and new nets. At IVCC, we are leading the implementation of the New Nets Project which began in 2019 in Burkina Faso and will expand in 2020 to Côte d’Ivoire, Mali, Mozambique, Nigeria and Rwanda. The pilot project is funded by Unitaid and the Global Fund. The Bill & Melinda Gates Foundation and U.S. Agency for International Development are providing supplementary funding. And, in October 2019, MedAccess and the foundation announced an agreement with a mosquito net manufacturer to accelerate the availability of 35 million new nets. Ultimately the project and its partners seek to not only establish the necessary evidence base needed to support an appropriate policy recommendation, but to also make the new nets a sustainable choice for countries looking for the best value for money in controlling malaria.
“The milestone of delivering 2 billion life-saving nets is a hallmark example of effective global partnership and sustained commitment over the past two decades. As we enter a new decade, we must now step up action to meet the ambitious global targets of further reducing malaria deaths and cases significantly by 2030. Political commitment and engagement from all levels of society will be crucial to ensure we reach those most vulnerable – pregnant women and children under 5 in sub-Saharan Africa – who still suffer from malaria with life-saving mosquito nets. Equally, we need to continue investing in developing, testing and scaling up nets with new insecticides and active ingredients to stay ahead of the evolving mosquito.”
Dr Abdourahmane Diallo
CEO, RBM Partnership to End Malaria
Notes to Editors
To arrange an interview with a representative for an organisation referenced in this press release, please contact the RBM Partnership press office at Grayling on [email protected] or call +44 (0)20 3861 3747.
This video marking the announcement is available for media outlets to use and share, with credit to the RBM Partnership to End Malaria. Pre-recorded interviews with the below spokespeople and case studies are also available on request.
*Also available for further comment
To support this major milestone for global health and to engage in the celebration online, social media users can use #EndMalaria and #zeromalariastartswithme.
About the RBM Partnership to End Malaria
The RBM Partnership to End Malaria is the largest global platform for coordinated action against malaria. Originally established as Roll Back Malaria (RBM) Partnership in 1998, it mobilises for action and resources and forges consensus among partners. The Partnership is comprised of more than 500 partners, including malaria endemic countries, their bilateral and multilateral development partners, the private sector, nongovernmental and community-based organisations, foundations, and research and academic institutions. www.endmalaria.org
IVCC is the only Product Development Partnership (PDP) working in vector control. IVCC was established in 2005, through a $50million grant to the Liverpool School of Tropical Medicine (LSTM) from the Bill & Melinda Gates Foundation, and is a registered charity in the UK. We work with stakeholders to facilitate the development of novel and improved public health insecticides and formulations to combat the rapidly growing problem of insecticide resistance. We bring together partners from industry, the public sector and academia to create new solutions to prevent disease transmission. By focusing resources and targeting practical scientific solutions we accelerate the process from innovation to impact.